Copyright © 2024 Open Medicine Foundation. All Rights Reserved.
The study will meticulously analyze daily changes in metabolites from blood samples of individuals with ME/CFS over 25 days, to uncover the complex biological processes contributing to the condition and facilitate patient clustering by dynamic changes, thereby addressing the challenge of clinical and biological diversity within the ME/CFS population.
Jarred Younger, BA, PhD
Christopher Armstrong, PhD
IRB/Ethics approval completed.
Samples are all collected.
Data collection complete and analysis nearly complete.
Paper drafting has begun but waiting for more guidance on data analysis workflow.
Another 3 months needed until paper submission.
We’re investigating how disruptions in energy metabolism play a role in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). While past studies have found differences in certain substances in the blood of people, there’s no consistent marker found yet. This might be because ME/CFS patients are quite diverse in both their symptoms and biology.
To tackle this, our study uses a method called repeated-measures design. This helps reduce differences between individuals and makes our findings more reliable, especially for conditions like ME/CFS where there’s a lot of variability.
We’re collecting blood samples from ME/CFS patients every day for 25 days. By carefully analyzing these samples using this method, we hope to understand better how the body’s chemistry changes over time in ME/CFS. Our aim is to group patients based on these changing patterns rather than just their static traits, which could lead to better ways to understand and treat ME/CFS in the future.
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